The high compression ratio of the K series is your biggest problem to iron out. You could stroke it and decrease the compression ratio then add a twin charge setup.
I would say it's better to have a supercharger and turbo on the Honda engines than a twin turbo, or you'll get quite a bit of lag.
How are you going to manage the mapping and fuelling? Hondata? Megasquirt? Bigger fuel pump and injectors/direct injection?