Chances are if you fit 4 piston calipers in place of singles you will need a larger bore master cylinder otherwise the pedal travel would be too great. This is due to the fact that brake fluid is not perfect, it is slightly compressible. A larger bore master would require a larger servo to retain the same pedal pressures. That said, many cars are over servoed so it may not be essential.
VW/Audi had a habit of ridiculously over assisting brakes in the mid to late 1990s. I am thinking Audi A4 and Golf GTi that I drove back to back at that time. The merest touch on the pedal would stand the car on it's front bumper and nearly pop your eyeballs from their sockets. It's all fine when you apply them for the second time, very easy to compensate.
So much so that getting back into the 2.0 midrange-ish Montego I had at the time made it feel like there were no brakes at all. (Not totally untrue either - they didn't stop especially well).
I like the old Citroen way of doing things - pressurise the whole system - vacuum servo assistance strikes me as crude in comparison.
Brake setup is a vague science or a precise art depending upon your stance. Most cars are fairly heavily front biased to reduce risk of sudden oversteer during braking. Pre-emptive brake force distribution is good - it's pretty much universal now I think.